Publications

Lab Cabezas-Wallscheid

*equal contributions, #co-corresponding author, †co-last author, ’co first-author

GPRC5C Drives Branched-Chain Amino Acid Metabolism in Leukemogenesis
Zhang YW, Velasco-Hernandez T, Mess J, Lalioti ME, Romero-Mulero MC, Obier N, Karantzelis N, Rettkowski J, Schönberger K, Karabacz N, Jäcklein K, Morishima T, Trincado JL, Romecin P, Martinez-Moreno A, Takizawa H, Shoumariyeh K, Renders S, Zeiser R, Pahl HL, Béliveau F, Hébert J, Lehnertz B, Sauvageau G, Menendez P, Cabezas-Wallscheid N (2023)
Blood Advances 2023010460.

Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia
Zhang YW, Schönberger K, Cabezas-Wallscheid N (2023)
EMBO Journal, e112348.

Enjoying the freedom to decide my research path
Interview with Nina Cabezas-Wallscheid by Van Emmenis L (2023)
Journal of Experimental Medicine 220(10), e20231561.

How Nutrition Regulates Hematopoietic Stem Cell Features
Schönberger K, Cabezas-Wallscheid N (2023)
Experimental Hematology, S0301-472X(23)01735-6.

VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells
Rosales-Alvarez RE, Rettkowski J, Herman JS, Dumbović G, Cabezas-Wallscheid N, Grün D (2023)
Genome Biology 24(1), 148.

CD53 sends HSCs to sweet DREAMs.
Karabacz N, Cabezas-Wallscheid N (2023)
Blood 141(10), 1100-1101.

LC-MS-Based Targeted Metabolomics for FACS-Purified Rare Cells
Schönberger K, Mitterer M, Glaser K, Stecher M, Hobitz S, Schain-Zota D, Schuldes K, Lämmermann T, Rambold AS, Cabezas-Wallscheid N, Buescher JM (2023)
Analytical Chemistry 95(9), 4325-4334.

Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity
López DA, Apostol AC, Lebish EJ, Valencia CH, Romero-Mulero MC, Pavlovich PV, Hernandez GE, Forsberg EC, Cabezas-Wallscheid N, Beaudin AE (2022)
Cell Reports 41(8), 111677.

Suppressed serological vitamin A in patients with liver cirrhosis is associated with impaired liver function and clinical detoriation
Nagel M, Labenz C, Dobbermann H, Czauderna C, Cabezas-Wallscheid N, Schattenberg JM, Wörns MA, Galle PR, Marquardt JU (2022)
European Journal of Gastroenterology & Hepatology 34(10), 1053-1059.

The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity
Grzejda D, Mach J, Schweizer JA, Hummel B, Rezansoff AM, Eggenhofer F, Panhale A, Lalioti ME, Cabezas Wallscheid N, Backofen R, Felsenberg J, Hilgers V (2022)
Science Advances 8(39), eabo5578.

HSCs: slow me down with PLAG1
Zhang YW, Cabezas-Wallscheid N (2022)
Blood 140(9), 935-936.

TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages
Schuster EM, Epple MW, Glaser KM, Mihlan M, Lucht K, Zimmermann JA, Bremser A, Polyzou A, Obier N, Cabezas-Wallscheid N, Trompouki E, Ballabio A, Vogel J, Buescher JM, Westermann AJ, Rambold AS (2022)
Nature Metabolism 4(7), 856-866.

Metabolic Regulation of Hematopoietic Stem Cells
Morganti C, Cabezas-Wallscheid N, Ito K (2022)
Hemasphere 6(7), e740.

Hyaluronic acid – GPRC5C signalling promotes dormancy in hematopoietic stem cells
Zhang YW’, Mess J’, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti ME, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D, Cabezas-Wallscheid N (2022)
Nature Cell Biology 24, 1038-1048.

Targeted low-input LC-MS based metabolomics and lipidomics on hematopoietic stem cells
Schönberger K, Mitterer M, Buescher JM^†, Cabezas-Wallscheid N^† (2022)
STAR Protocols (Cell Press Journal): 3(2), 101408.

P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction
Seung H, Wrobel J, Wadle C, Bühler T, Chiang D, Rettkowski J, Cabezas-Wallscheid N, Hechler B, Stachon P, Maier A, Weber C, Wolf D, Duerschmied D, Idzko M, Bode C, von Zur Mühlen C, Hilgendorf I, Heidt T (2022)
Basic Research in Cardiology 117 (16).

Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity
Schönberger K*, Obier N*, Romero-Mulero MC, Cauchy P,  Mess J, Pavlovich PV, Zhang YW, Mitterer M, Rettkowski J, Lalioti ME, Jäcklein K, Curtis JD,  Féret B, Sommerkamp P, Morganti C, Ito K, Ghyselinck NB, Trompouki E, Buescher JM, Pearce EL and Cabezas-Wallscheid N (2022)
Cell Stem Cell 29(1), 131-148.e10.

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo
Spohr C, Poggio T, Andrieux G, Schönberger K, Cabezas-Wallscheid N, Boerries M, Halbach S, Illert AL, Brummer T (2022)
Leukemia, 36, 970–982.

Avoid shocking your hematopoietic stem cells to keep them young and growing
Lalioti ME, Rettkowski J, Cabezas-Wallscheid N (2021)
Cell Stem Cell 28(11), 1887-1889.

The simplified MPP isolation scheme: establishing a consensus approach for multipotent progenitor identification
Challen GA*, Pietras EM*, Cabezas-Wallscheid N*, Signer RAJ* (2021)
Experimental Hematology 104, 55-63.

Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration
Clapes T, Polyzou A, Pia Prater, Sagar, Morales-Hernández A, Galvao Ferrarini M, Hummel B, Obier N, Maticzka D, Lefkopoulos S, Kehrer N, Bergo V, Bridgeman A, Herman JS, Ilik I, Klaeylé L, Rehwinkel J, McKinney-Freeman S, Backofen R, Akhtar A, Cabezas-Wallscheid N, Sawarkar R, Rebollo R, Grün D, Trompouki E (2021)
Natur Cell Biology 23(7), 704-717.

Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis
Spiecker L, Witte I, Mehlig J, Shah V, Meyerhöfer M, Haehnel PS, Petermann V, Schüler A, More P, Cabezas-Wallscheid N, Horke S, Pautz A, Daiber A, Sasca D, Kindler T, Kleinert H (2021)
Oxidative Medicine and Cellular Longevity 2021, 3917028.

Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation (Review)
Sommerkamp P, Cabezas-Wallscheid N^†, Trumpp A^✝︎ (2021)
Trends in Molecular Medicine 27(7), 660-672.

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells
Sommerkamp P’, Romero-Mulero MC’, Narr A’, Ladel L’, Hustin LSP, Schönberger K, Renders S, Altamura S, Zeisberger P, Jäcklein K, Klimmeck D, Rodriguez-Fraticelli AE, Camargo F, Perié L, Trumpp A^† & Cabezas-Wallscheid N^† (2021) 
Blood 137(23), 3218-3224.

Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N^#† & Trumpp A^#† (2021)
Nature Communications 12, 608.

Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism 
Sommerkamp P, Altamura S, Renders S, Narr A, Ladel L, Zeisberger P, Eiben PL, Fawaz M, Rieger MA, Cabezas-Wallscheid N^*#† , Trumpp A^*#†  (2020) 
Cell Stem Cell 26(5), 722-738.e7.

• Previewed by Shuai Jiang in Cell Stem Cell. APA makes a short cut for ramping up HSC metabolism

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations
Kokkaliaris K, Kunz L, Cabezas-Wallscheid N, Christodoulou C, Renders S, Camargo F, Trumpp A, Scadden DT, Schroeder T (2020)
Blood 136, 2296-2307.

Single-cell lineage tracing approaches in hematology research - technical considerations
Carrelha J, Lin DS, Rodriguez-Fraticelli AE, Luis TC, Wilkinson AC, Cabezas-Wallscheid N, Tremblay CS, Haas S (2020) 
Experimental Hematology 89, 26-36.

Loss of the Fanconi anemia-associated protein Nipa causes bone marrow failure
Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Mueller-Rudorf A, Zwick M, Rückert T, Pantic M, Poggio T, Shoumariyeh K, Mueller TA, Kawaguchi H, Follo M, Klingeberg C, Wlodarski M, Baumann I, Pfeifer D, Kulinski M, Rudelius M, Lemeer S, Kuster B, Dierks C, Peschel C, Cabezas-Wallscheid N, Duque-Afonso J, Zeiser R, Cleary ML, Schindler D, Schmitt-Graeff A, Boerries M, Niemeyer CM, Oostendorp RA, Duyster J, Illert AL (2020) 
The Journal of Clinical Investigation, 130, 2827-2844.

Characterizing the In Vivo Role of Candidate Leukemia Stem Cell Genes.
Zhang YW, Mess J, & Cabezas-Wallscheid N (2021)
MiMB Springer Nature. Methods in Molecular Biology,  2185 , 307-316.

Haematopoietic stem cells in perisinusoidal niches are protected from ageing 
Saçma M, Pospiech J, Bogeska R, de Back W, Mallm JP, Sakk V, Soller K, Marka G, Vollmer A, Karns R, Cabezas-Wallscheid N, Trumpp A, Méndez-Ferrer S, Milsom MD, Mulaw MA, Geiger H, Florian MC (2019) 
Nature Cell Biology 21, 1309-1320.

Assessment of young and aged hematopoietic stem cell activity by competitive serial transplantation assays 
Zhang YW and Cabezas-Wallscheid N (2019) 
In: Klein G., Wuchter P. (eds) Stem Cell Mobilization. Methods in Molecular Biology, vol. 2017, Humana, New York, NY, 193-203.

Advice for the Next Generation 
Cabezas-Wallscheid N (2019) 
Cell Stem Cell 24, 515-517.

• Invitation from Cell Stem Cell: Series of interviews published over the year 2019 to six early stage PIs.

The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells  
Sommerkamp P, Renders S, Ladel L, Hotz-Wagenblatt A, Schönberger K, Zeisberger P, Przybylla A, Sohn M, Zhou Y, Klibanski A, Cabezas-Wallscheid^*#, Trumpp A^*# (2019) 
Scientific Reports 9:2110.

Aging alters the epigenetic asymmetry of HSC division 
Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H (2018) 
PLoS Biology 16(9): e2003389. 

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis 
Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, Jaitin D, Cabezas-Wallscheid N, Dress R, Ginhoux F, Trumpp A, Tanay A, Amit I (2018) 
Nature Cell Biology 20, 836-846.

Vitamin C: C-ing a New Way to Fight Leukemia 
Schönberger K, Cabezas-Wallscheid N (2017) 
Cell Stem Cell 21(5), 561-563.

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy 
Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck P, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P,  Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian KM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A (2017) 
Cell 169(5), 807-823.

• Selected for Cell Video Abstract: Awakening Stem Cells with Vitamins (youtube)
• Previewed by Alexandra Rundberg Nilsson and Cornelis Jan Pronk in Cell Stem Cell “Retinoic Acid Puts Hematopoietic Stem Cells Back To Sleep”

“Potency finds its niches”. Stem Cells. 
Cabezas-Wallscheid N, Trumpp A (2016) 
Science 351(6269), 126-127.

Myc depletion induces a pluripotent dormant State mimicking diapause 
Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A (2016) 
Cell 164(4), 668-680.

• Cover of the Cell February Issue
• Previewed by Xiaodong Shu and Duanqing Pei in Cell. “Pluripotency without proliferation“
• Previewed by Nakagawa M, Karagiannis P, Yamanaka S in EMBO Journal. “When Myc's asleep, embryonic stem cells are dormant“

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis 
Cabezas-Wallscheid N*, Klimmeck D*, Hansson J*, Lipka DB*, Reyes A*, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A (2014) 
Cell Stem Cell 15(4), 507-522.

• Cover of the Cell Stem Cell October Issue
• Top 5% of all Cell Stem Cell articles ranked by attention on Aug. 2015 (Article Level Metrics; Cell Press)
• Previewed by D. Kalaitzidis and D.T. Scadden in EMBO Journal. “Deep diving in the blood stem cell-ome”

Transcriptome-wide Profiling and Posttranscriptional Analysis of Hematopoietic Stem/Progenitor Cell Differentiation toward Myeloid Commitment 
Klimmeck D*, Cabezas-Wallscheid N*, Reyes A*, von Paleske L, Renders S, Hansson J, Krijgsveld J, Huber W, Trumpp A (2014) 
Stem Cell Reports 3(5), 858-875.

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing 
Lipka DB*, Wang Q*, Cabezas-Wallscheid N*, Klimmeck D*, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C (2014)  
Cell Cycle 13(22), 3476-3487.

• Previewed by SM. Cullen and MA. Goodell in Cell Cycle. “Dynamic DNA methylation discovered during HSC differentiation”

Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking Granzyme B 
Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jöckel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, Trumpp A (2014) 
Journal of Experimental Medicine 211(5), 769-779.

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model 
Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A, Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R, Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC, Trumpp A, Sahin U, Bockamp E (2013) 
EMBO Molecular Medicine 5(12), 1804-1820.

• Previewed by J. Mulloy in EMBO Mol Med. “A new inducible model for t(8;21) AML”

Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression 
Wörtge S, Eshkind L, Cabezas-Wallscheid N, Lakaye B, Kim J, Heck R, Abassi Y, Diken M, Sprengel R, Bockamp E (2010) 
BMC Developmental Biology 10:95.

In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice 
Bockamp E, Antunes C, Liebner S, Schmitt S, Cabezas-Wallscheid N, Heck R, Ohnngemach S, Oesch-Bartlomowicz B, Rickert C, Sanchez MJ, Hengstler J, Kaina B, Wilson A, Trumpp A, Eshkind L (2009) 
Mechanisms of Development 126(10), 863-872.

Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system 
Bockamp E, Christel C, Hameyer D, Khobta A, Maringer M, Reis M, Heck R, Cabezas-Wallscheid N, Epe B, Oesch-Bartlomowicz B, Kaina B, Schmitt S, Eshkind L (2007) 
Journal of Gene Medicine 9(4), 308-318.

Find more publications by Nina Cabezas-Wallscheid on Pubmed.