Publications of David O'Sullivan

Villa, M.; O'Sullivan, D.; Pearce, E. L.: Glucose makes T_reg lose their temper. Cancer Cell 39, pp. 460 - 462 (2021)

Corrado, M.; Edwards-Hicks, J.; Villa, M.; Flachsmann, L. J.; Sanin, P. D. E.; Jacobs, M.; Baixauli Celda, F.; Stanczak, M.; Anderson, E.; Azuma, M. et al.; Quintana, A.; Jonathan, C.; Clapes, T.; Grzes, K.; Kabat, A.; Ryan, K.; Annette, E. P.; Klein-Geltink, R.; Amulic, B.; Steward, C. G.; Strathdee, D.; Trompouki, E.; O'Sullivan, D.; Pearce, E. J.; Pearce, E. L.: Dynamic Cardiolipin Synthesis Is Required for CD8⁺ T Cell Immunity. Cell Metabolism 32, pp. 981 - 995 (2020)

Uhl, F. M.; Chen, S.; O'Sullivan, D.; Edwards-Hicks, J.; Richter, G.; Haring, E.; Andrieux, G.; Halbach, S.; Apostalova, P.; Büscher, J. M. et al.; Duquesne, S.; Melchinger, W.; Sauer, B.; Shoumariyeh, K.; Schmitt-Graeff, A.; Kreutz, M.; Lübbert, M.; Duyster, J.; Brummer, T.; Boerries, M.; Madl, T.; Blazar, B. R.; Groß, O.; Pearce, E. L.; Zeiser, R.: Metabolic reprogramming of donor T cells enhances graf-versus-leukemia effects in mice and humans. Science translational medicine: integrating medicine and science / American Association for the Advancement of Science 12, p. eabb8969 (2020)

Klein-Geltink, R.; Edwards-Hicks, J.; Apostolova, P.; O'Sullivan, D.; Sanin, P. D. E.; Annette, E. P.; Puleston, D.; Ligthart, N. A. M.; Büscher, J. M.; Grzes, K. et al.; Kabat, A.; Stanczak, M.; Curtis, J.; Hässler, F.; Uhl, F. M.; Fabri, M.; Zeiser, R.; Pearce, E. J.; Pearce, E. L.: Metabolic conditioning of CD8⁺ effector T cells for adoptive cell therapy. Nature Metabolism 2, pp. 703 - 716 (2020)

O'Sullivan, D.: The metabolic spectrum of memory T cells. Immunology and Cell Biology 97, pp. 636 - 646 (2019)

O'Sullivan, D.; Sanin, P. D. E.; Pearce, E. J.; Pearce, E. L.: Metabolic interventions in the immune response to cancer. Nature Reviews Immunology 19, pp. 324 - 334 (2019)

Sanin, D. E.; Matsushita, M.; Klein-Geltink, R.; Grzes, K.; van Bakker, N. T.; Corrado, M.; Kabat, A.; Buck, M. D.; Qiu, J.; Lawless, S. J. et al.; Cameron, A.; Villa, M.; Baixauli Celda, F.; Patterson, A. E.; Hässler, F.; Curtis, J. D.; O’Neill, C. M.; O'Sullivan, D.; Wu, D.; Mittler, G.; Huang, S. C.-C.; Pearce, E. L.; Pearce, E. J.: Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity 49, pp. 1021 - 1033 (2018)

Mathew, N. R.; Baumgartner, F.; Braun, L.; O'Sullivan, D.; Thomas, S.; Waterhouse, M.; Müller, T. A.; Hanke, K.; Taromi, S.; Apostolova, P. et al.; Illert, A. L.; Melchinger, W.; Duquesne, S.; Schmitt-Graeff, A.; Osswald, L.; Yan, K.-L.; Weber, A.; Tugues, S.; Spath, S.; Pfeifer, D.; Follo, M.; Claus, R.; Lübbert, M.; Rummelt, C.; Bertz, H.; Wäsch, R.; Haag, J.; Schmidts, A.; Schultheiss, M.; Bettinger, D.; Thimme, R.; Ullrich, E.; Tanriver, Y.; Vuong, G. L.; Arnold, R.; Hemmati, P.; Wolf, D.; Ditschkowski, M.; Jilg, C.; Wilhelm, K.; Leiber, C.; Gerull, S.; Halter, J.; Lengerke, C.; Pabst, T.; Schroeder, T.; Kobbe, G.; Rösler, W.; Doostkam, S.; Meckel, S.; Stabla, K.; Metzelder, S. K.; Halbach, S.; Brummer–, T.; Hu, Z.; Dengjel, J.; Hackanson, B.; Schmid, C.; Holtick, U.; Scheid, C.; Spyridonidis, A.; Stölzel, F.; Ordemann, R.; Müller, L. P.; Sicre-de-Fontbrune, F.; Ihorst, G.; Kuball, J.; Ehlert, J. E.; Feger, D.; Wagner, E.-M.; Cahn, J.-Y.; Schnell, J.; Kuchenbauer, F.; Bunjes, D.; Chakraverty, R.; Richardson, S.; Gill, S.; Kröger, N.; Ayuk, F.; Vago–, L.; Ciceri–, F.; Müller, A. M.; Kondo, T.; Teshima, T.; Klaeger, S.; Kuster, B.; Kim, D.; Weisdorf, D.; van der Velden, W.; Dörfel, D.; Bethge, W.; Hilgendorf, I.; Hochhaus, A.; Andrieux, G.; Börries, M.; Busch, H.; Magenau, J.; Reddy, P.; Labopin, M.; Antin, J. H.; Henden, A. S.; Hill–, G. R.; Kennedy, G. A.; Bar, M.; Sarma, A.; McLornan, D.; Mufti, G.; Oran, B.; Rezvani, K.; Shah, O.; Negrin, R. S.; Nagler, A.; Prinz, M.; Burchert, A.; Neubauer, A.; Beelen, D.; Mackensen, A.; von Bubnoff, N.; Herr, W.; Becher, B.; Socié, G.; Caligiuri, M. A.; Ruggiero–, E.; Bonini–, C.; Häcker, G.; Duyster, J.; Finke, J.; Pearce, E. L.; Blazar, B. R.; Zeiser, R.: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT-3-ITD-mutant leukemia cells. Nature Medicine 24, pp. 282 - 291 (2018)

Prestipino, A.; Emhardt, A. J.; Aumann, K.; O'Sullivan, D.; Gorantla, S. P.; Duquesne, S.; Melchinger, W.; Braun, L.; Vuckovic, S.; Boerries, M. et al.; Busch, H.; Halbach, S.; Pennisi, S.; Poggio, T.; Apostolova, P.; Veratti, P.; Hettich, M.; Niedermann, G.; Bartholomä, M.; Shoumariyeh, K.; Jutzi, J. S.; Wehrle, J.; Dierks, C.; Becker, H.; Schmitt-Graeff, A.; Follo, M.; Pfeifer, D.; Rohr, J.; Fuchs, S.; Ehl, S.; Hartl, F. A.; Minguet, S.; Miething, C.; Heidel, F. H.; Kröger, N.; Triviai, I.; Brummer, T.; Finke, J.; Illert, A. L.; Ruggiero, E.; Bonini, C.; Duyster, J.; Pahl, H. L.; Lane, S. W.; Hill, G. R.; Blazar, B. R.; von Bubnoff, N.; Pearce, E. L.; Zeiser, R.: Oncogenic JAK2^V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science translational medicine: integrating medicine and science / American Association for the Advancement of Science 10, p. eaam7729 (2018)

Klein-Geltink, R.; O'Sullivan, D.; Pearce, E. L.: Caught in the cROssfire: GSH Controls T Cell Metabolic Reprogramming. Immunity 46, pp. 525 - 527 (2017)

O'Sullivan, D.; Kelly, B.; Pearce, E. L.: When Hexokinase Gets that NAG-ing Feeling. Cell Metabolism 24, pp. 198 - 200 (2016)

Chang, C.-H.; Qiu, J.; O'Sullivan, D.; Buck, M.; Noguchi, T.; Curtis, J. D.; Chen, Q.; Gindin, M.; Gubin, M. M.; van der Windt, G. J.W. et al.; Tonc, E.; Schreiber, R. D.; Pearce, E. J.; Pearce, E. L.: Metabolic Competition in the Tumor Microenvironment is a Driver of Cancer Progression. Cell 162, pp. 1229 - 1241 (2015)

Buck, M. D.; O'Sullivan, D.; Pearce, E. L.: T cell metabolism drives immunity. Journal of Experimental Medicine 212, pp. 1345 - 1360 (2015)

O'Sullivan, D.; Pearce, E. L.: Immunology, Expanding the roles of metabolism in T cells. Science 348, pp. 976 - 977 (2015)

O'Sullivan, D.; Pearce, E. L.: Targeting T cell metabolism for therapy. Trends in Immunology 36, pp. 71 - 80 (2015)

O'Sullivan, D.; Pearce, E. L.: Fatty acid sysnthesis tips the TH17-Treg cell balance. Nature Medicine 20, pp. 1235 - 1236 (2014)

Huang, S. C.-C.; Everts, B.; Ivanova, Y.; O'Sullivan, D.; Nascimento, M.; Smith, A. M.; Beatty, W.; Love-Gregory, L.; Lam, W. Y.; O'Neill, C. M. et al.; Yan, C.; Du, H.; Abumrad, N. A.; Urban, J. F. J.; Artyomov, M. N.; Pearce, E. J.; Pearce, E. L.: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology 15, pp. 846 - 855 (2014)

O'Sullivan, D.; van der Windt, G. J.W.; Huang, S. C.-C.; Curtis , J.; Chang, C.-H.; Buck, M. D.; Qiu, J.; Smith, A. M.; Lam, W. Y.; DiPlato, L. M. et al.; Hsu, F.-F.; Birnbaum, M. J.; Pearce, E. J.; Pearce, E. L.: Memory CD8⁺ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, pp. 75 - 88 (2014)