Publications of Eirini Trompouki

Greiner-Tollersrud, O. K.; Krausz, M.; Boehler, V.; Polyzou, A.; Seidl, M.; Spahiu, A.; Abdullah, Z.; Andryka-Cegielski, K.; Dominick, F. I.; Huebscher, K. et al.; Goschin, A.; Smulski, C. R.; Trompouki, E.; Link, R.; Ebersbach, H.; Srinivas, H.; Marchant, M.; Sogkas, G.; Staab, D.; Vågbø, C.; Guerini, D.; Baasch, S.; Latz, E.; Hartmann, G.; Henneke, P.; Geiger, R.; Peng, X. P.; Grimbacher, B.; Bartok, E.; Alseth, I.; Warncke, M.; Proietti, M.: ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA. Cell Reports 43, 114899 (2024)

Boumpas, A.; Papaioannou, A. S.; Bousounis, P.; Grigoriou, M.; Bergo, V.; Papafragkos, I.; Tasis, A.; Iskas, M.; Boon, L.; Makridakis, M. et al.; Vlachou, A.; Gavriilaki, E.; Hatzioannou, A.; Mitroulis, I.; Trompouki, E.; Verginis, P.: PD-L1 blockade immunotherapy rewires cancer-induced emergency myelopoiesis. Frontiers in Immunology 15, 1386838 (2024)

Beckmann, C. C. A.; Ramamoorthy, S.; Trompouki, E.; Driever, W.; Schwarz-Furlan, S.; Strahm, B.; Yoshimi, A.; Niemeyer, C. M.; Erlacher, M.; Kapp, F. G.: Assessment of a novel NRAS in-frame tandem duplication causing a myelodysplastic/myeloproliferative neoplasm. Experimental Hematology 133, 104207 (2024)

Schuster, E.-M.; Epple, M. W.; Glaser, K. M.; Mihlan, M.; Lucht, K.; Zimmermann, J. A.; Bremser, A.; Polyzou, A.; Obier, N.; Cabezas-Wallscheid, N. et al.; Trompouki, E.; Ballabio, A.; Vogel, J.; Büscher, J. M.; Westermann, A. J.; Rambold, A.: TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages. Nature Metabolism 4, pp. 856 - 866 (2022)

Schönberger, K.; Obier, N.; Romero-Mulero, M. C.; Cauchy, P.; Mess, J.; Pavlovich, P. V.; Zhang, Y. W.; Mitterer, M.; Rettkowski, J.; Lalioti, M.-E. et al.; Jäcklein, K.; Curtis, J. D.; Féret, B.; Sommerkamp, P.; Morganti, C.; Ito, K.; Ghyselinck, N. B.; Trompouki, E.; Büscher, J. M.; Pearce, E. L.; Cabezas-Wallscheid, N.: Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity. Cell Stem Cell 29, pp. 131 - 148 (2022)

Bowman, T. V.; Trompouki, E.: Sensing Stemness. Current Stem Cell Reports 7, pp. 219 - 228 (2021)

Clapes, T.; Polyzou, A.; Prater, P.; Sagar; Morales-Hernández, A.; Ferrarini, M. G.; Kehrer, N.; Lefkopoulos, S.; Bergo, V.; Hummel, B. et al.; Obier, N.; Maticzka, D.; Bridgeman, A.; Herman, J. S.; Ilik, I.; Klaeylé, L.; Rehwinkel, J.; McKinney-Freeman, S.; Backofen, R.; Akhtar, A.; Cabezas-Wallscheid, N.; Sawarkar, R.; Rebollo, R.; Grün, D.; Trompouki, E.: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature Cell Biology 23, pp. 704 - 717 (2021)

Antonio Urrutia, G.; Ramachandran, H.; Cauchy, P.; Boo, K.; Ramamoorthy, S.; Boller, S.; Dogan, E.; Clapes, T.; Trompouki, E.; Torres-Padilla, M.-E. et al.; Palvimo, J. J.; Pichler, A.; Grosschedl, R.: ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation. Genes and Development 35, pp. 1143 - 1160 (2021)

Bousounis, P.; Bergo, V.; Trompouki, E.: Inflammation, Aging and Hematopoiesis: A Complex Relationship. Cells 10, 1386 (2021)

Trompouki, E.: Mixing “good and bad” annoys neutrophils. Blood 137, pp. 1272 - 1274 (2021)

Corrado, M.; Edwards-Hicks, J.; Villa, M.; Flachsmann, L. J.; Sanin, P. D. E.; Jacobs, M.; Baixauli Celda, F.; Stanczak, M.; Anderson, E.; Azuma, M. et al.; Quintana, A.; Jonathan, C.; Clapes, T.; Grzes, K.; Kabat, A.; Ryan, K.; Annette, E. P.; Klein-Geltink, R.; Amulic, B.; Steward, C. G.; Strathdee, D.; Trompouki, E.; O'Sullivan, D.; Pearce, E. J.; Pearce, E. L.: Dynamic Cardiolipin Synthesis Is Required for CD8⁺ T Cell Immunity. Cell Metabolism 32, pp. 981 - 995 (2020)

Choudhuri, A.; Trompouki, E.; Abraham, B. J.; Colli, L. M.; Kock, K. H.; Mallard, W.; Yang, M.-L.; Vinjamur, D. S.; Ghamari, A.; Sporrij, A. et al.; Hoi, K.; Hummel, B.; Boatman, S.; Chan, V.; Tseng, S.; Nandakumar, S. K.; Yang, S.; Lichtig, A.; Superdock, M.; Grimes, S. N.; Bowman, T. V.; Zhou, Y.; Takahashi, S.; Joehanes, R.; Cantor, A. B.; Bauer, D. E.; Ganesh, S. K.; Rinn, J.; Albert, P. S.; Bulyk, M. L.; Chanock, S. J.; Young, R. A.; Zon, L. I.: Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nature Genetics 52, pp. 1333 - 1345 (2020)

Lefkopoulos, S.; Polyzou, A.; Derecka, M.; Bergo, V.; Clapes, T.; Cauchy, P.; Jerez-Longres, C.; Onishi-Seebacher, M.; Yin, N.; Martagon-Calderón, N.-A. et al.; Potts, K. S.; Klaeylé, L.; Liu, F.; Bowman, T. V.; Jenuwein, T.; Mione, M. C.; Trompouki, E.: Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the emergence of Hematopoietic Stem and Progenitor Cells. Immunity 53, pp. 934 - 951 (2020)

Ferrari, F.; Arrigoni, L.; Franz, H.; Izzo, A.; Butenko, L.; Trompouki, E.; Vogel, T.; Manke, T.: DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility. Nature Communications 11, p. 5200 (2020)

Hsu, J.; Huang, H.-T.; Lee, C.-T.; Choudhuri, A.; Wilson, N. K.; Abraham, B. J.; Moignard, V.; Kucinski, I.; Yu, S.; Hyde, R. K. et al.; Tober, J.; Cai, X.; Li, Y.; Guo, Y.; Yang, S.; Superdock, M.; Trompouki, E.; Calero-Nieto, F. J.; Ghamari, A.; Jiang, J.; Gao, P.; Gao, L.; Nguyen, V.; Robertson, A. L.; Durand, E. M.; Kathrein, K. L.; Aifantis, I.; Gerber, S. A.; Tong, W.; Tan, K.; Cantor, A. B.; Zhou, Y.; Liu, P. P.; Young, R. A.; Göttgens, B.; Speck, N. A.; Zon, L. I.: CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America 117, pp. 23626 - 23635 (2020)

Clapes, T.; Trompouki, E.: Hematopoietic regeneration under the spell of epigenetic-epitranscriptomic factors and transposable elements. Current Opinion in Hematology 27, pp. 264 - 272 (2020)

Kozyra, E. J.; Pastor, V. B.; Lefkopoulos, S.; Sahoo, S. S.; Busch, H.; Voss, R. K.; Erlacher, M.; Lebrecht, D.; Szvetnik, E. A.; Hirabayashi, S. et al.; Pasaulienė, R.; Pedace, L.; Tartaglia, M.; Klemann, C.; Metzger, P.; Boerries, M.; Catala, A.; Hasle, H.; de Haas, V.; Kállay, K.; Masetti, R.; Moerloose, B. D.; Dworzak, M.; Schmugge, M.; Smith, O.; Starý, J.; Mejstrikova, E.; Ussowicz, M.; Morris, E.; Singh, P.; Collin, M.; Dereka, M.; Göhring, G.; Flotho, C.; Strahm, B.; Locatelli, F.; Niemeyer, C. M.; Trompouki, E.; Wlodarski, M. W.; EWOG-MDS, W. G.: Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency. Leukemia: the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K. 34, pp. 2673 - 2687 (2020)

Siamishi, I.; Iwanami, N.; Clapes, T.; Trompouki, E.; O'Meara, C. P.; Boehm, T.: Lymphocyte-Specific Function of the DNA Plymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles. Cell Reports 31, 107756 (2020)

de Pater, E.; Trompouki, E.: Bloody Zebrafish: Novel methods in Normal and Malignant Hematopoiesis. Frontiers in Cell Development and Biology 6, p. 124 (2018)

Kapp, F. G.; Perlin, J. R.; Hagedorn, E. J.; Gansner, J. M.; Schwarz, D. E.; O’Connell, L. A.; Johnson, N. S.; Amemiya, C.; Fisher, D. E.; Wölfle, U. et al.; Trompouki, E.; Niemeyer, C. M.; Driever, W.; Zon, L. I.: Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature 558, pp. 445 - 448 (2018)

Piragyte, I.; Clapes, T.; Polyzou, A.; Geltink, R. I. K.; Lefkopoulos, S.; Yin, N.; Cauchy, P.; Curtis, J. D.; Klaeylé, L.; Langa, X. et al.; Beckmann, C. C. A.; Wlodarski, M. W.; Müller, P.; Essen, D. V.; Rambold, A.; Kapp, F. G.; Mione, M.; Buescher, J. M.; Pearce, E. L.; Polyzos, A.; Trompouki, E.: A metabolic interplay coordinatd by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature Communications 9, p. 3090 (2018)

Trompouki, E.; Mullen, L.; Fernandez-Reyes, D.; Yodoi, J.; Kim, S.; Schuettpelz, L. G.: Inflammatory Signaling in Bone Marrow Failure and Hematopoietic Malignancy. Frontiers in immunology 8, p. 660 (2017)

van Rooij, F. J.A.; Qayyum, R.; Smith, A. V.; Zhou, Y.; Trompet, S.; Tanaka, T.; Keller, M. F.; Chang, L.-C.; Schmidt, H.; Yang, M.-L. et al.; Chen, M.-H.; Hayes, J.; Johnson, A. D.; Yanek, L. R.; Mueller, C.; Lange, L.; Floyd, J. S.; Ghanbari, M.; Zonderman, A. B.; Jukema, J. W.; Hofman, A.; van Duijn, C. M.; Desch, K. C.; Saba, Y.; Ozel, A. B.; Snively, B. M.; Wu, J.-Y.; Schmidt, R.; Fornage, M.; Klein, R. J.; Fox, C. S.; Matsuda, K.; Kamatani, N.; Wild, P. S.; Stott, D. J.; Ford, I.; Slagboom, P. E.; Yang, J.; Chu, A. Y.; Lambert, A. J.; Uitterlinden, A. G.; Franco, O. H.; Hofer, E.; Ginsburg, D.; Hu, B.; Keating, B.; Schick, U. M.; Brody, J. A.; Li, J. Z.; Chen, Z.; Zeller, T.; Guralnik, J. M.; Chasman, D. I.; Peters, L. L.; Kubo, M.; Becker, D. M.; Li, J.; Eiriksdottir, G.; Rotter, J. I.; Levy, D.; Grossmann, V.; Patel, K. V.; Chen, C.-H.; Project, T. B. J.; Ridker, P. M.; Tang, H.; Launer, L. J.; Rice, K. M.; Li-Gao, R.; Ferrucci, L.; Evans, M. K.; Choudhuri, A.; Trompouki, E.; Abraham, B. J.; Yang, S.; Takahashi, A.; Kamatani, Y.; Kooperberg, C.; Harris, T. B.; Jee, S. H.; Coresh, J.; Tsai, F.-J.; Longo, D. L.; Chen, Y.-T.; Felix, J. F.; Yang, Q.; Psaty, B. M.; Boerwinkle, E.; Becker, L. C.; Mook-Kanamori, D. O.; Wilson, J. G.; Gudnason, V.; O'Donnell, C. J.; Dehghan, A.; Cupples, L. A.; Nalls, M. A.; Morris, A. P.; Okada, Y.; Reiner, A. P.; Zon, L. I.; Ganesh, S. K.: Genome-wide Trans-ethnic meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. The American Journal of Human Genetics 100, pp. 51 - 63 (2017)

Trompouki, E.; Flores-Figueroa, E.; Lucas , D.; Bowman, T.C.: From the Bedside to the Bench: New Discoveries on Blood Cell Fate and Function. Experimental Hematology 47, pp. 24 - 30 (2017)

Aranda-Orgilles, B.; Saldaña-Meyer, R.; Wang, E.; Trompouki, E.; Fassl, A.; Lau, S.; Mullenders, J.; Rocha, P. P.; Raviram, R.; Guillamot, M. et al.; Sánchez-Díaz, M.; Wang, K.; Kayembe, C.; Zhang, N.; Amoasii, L.; Choudhuri, A.; Skok, J. A.; Schober, M.; Reinberg, D.; Sicinski, P.; Schrewe, H.; Tsirigos, A.; Zon, L. I.; Aifantis, I.: MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell 19, pp. 784 - 799 (2016)

Clapes, T.; Lefkopoulos, S.; Trompouki, E.: Stress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and Maintenance. Frontiers in immunology 7, p. e487 - e487 (2016)

Huang, J.; Liu, X.; Li, D.; Shao, Z.; Cao, H.; Zhang, Y.; Trompouki, E.; Bowman, T. V.; Zon, L. I.; Yuan, G.-C. et al.; Orkin, S. H.; Xu, J.: Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Developmental Cell 36, pp. 9 - 23 (2016)

Trompouki, E.: Fish provide ID(H)eas on targeting leukemia. Blood 125, pp. 2880 - 2882 (2015)

Lin , M. I.; Emily N., P.; Boatmann, S.; Hagedorn, E. J.; Trompouki, E.; Satishchandran, S.; Carspecken, C. W.; Uong, A.; DiBiase, A.; Yang, S. et al.; Canver, M. C.; Dahlberg, A.; Lu , Z.; Zhang, C. C.; Orkin, S. H.; Bernstein, I. D.; Aster, J. C.; White, R. M.; Zon, L. I.: Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. eLIFE 4, p. e05544 (2015)

Trompouki, E.; King, K. Y.; Will, B.; Lessard, J.; Flores-Figueroa, E.; Kokkaliaris, K. D.; Bowman, T.: Blood signals: from birth to disease and death. Experimental Hematology 42, pp. 989 - 994 (2014)