Publications of Manuel Modolell

Abebe, T.; Hailu, A.; Woldeyes, M.; Mekonen, W.; Bilcha, K.; Cloke, T.; Fry, L.; Seich al Basatena, N.-K.; Corware, K.; Modolell, M. et al.; Munder, M.; Tacchini-Cottier, F.; Müller, I.; Kropf, P.: Local Increase of Arginase Activity in Lesions of Patients with Cutaneous Leishmaniasis in Ethiopia. PLoS Neglected Tropical Diseases 6, p. e1684 - e1684 (2012)

Comalada, M.; Yeramian, A.; Modolell, M.; Lloberas, J.; Celeba, A.: Arginine and Macrophage Activation. Methods in Molecular Biology 844, pp. 223 - 235 (2012)

Varela-M, R. E.; Villa-Pulgarin, J. A.; Yepes, E.; Müller, I.; Modolell, M.; Munoz, D. L.; Robledo, S. M.; Muskus, C. E.; López-Abán, J.; Muro, A. et al.; Vélez, I. D.; Mollinedo, F.: In Vitro and In Vivo Efficacy of Ether Lipid Edelfosine against Leischmania spp. and SbV-Resistant Parasites. PLoS Neglected Tropical Diseases 6, p. e1612 - e1612 (2012)

Choi, B.-S.; Clara Martinez-Falero, I.; Corset, C.; Munder, M.; Modolell, M.; Müller, I.; Kropf, P.: Differential impact of L-Arginine deprivation on the activation and effector functions of T cells and macrophages. Journal of Leukocyte Biology 85, pp. 268 - 277 (2009)

Fitzpatrick, J.; Fuentes, J. M.; Chalmers, I. W.; Wynn, T. A.; Modolell, M.; Hoffmann, K. F.; Hesse, M.: Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. International Journal of Parasitology 39, pp. 267 - 279 (2009)

Modolell, M.; Choi, B.-S.; Ryan, R. O.; Hancock, M.; Titus, R. G.; Tamrat, A.; Hailu, A.; Müller, I.; Rogers, M. E.; Bangham, C. R. M. et al.; Munder, M.; Kropf, P.: Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depeletion in Nonhealing Leishmaniasis. PLoS Neglected Tropical Diseases 3, p. e480 - e480 (2009)

Mollinedo, F.; Gajate, C.; Morales, A. I.; del Canto-Janez, E.; Justies, N.; Collia, F.; Rivas, J. V.; Modolell, M.; Iglesias, A.: Novel Anti-Inflammatory Action of Edelfosine Lacking Toxicity with Protective Effect in Experimental Colitis. The Journal of Pharmacology and Experimental Therapeutics 329, pp. 439 - 449 (2009)

Müller, I.; Hailu, A.; Choi, B.-S.; Abebe, T.; Fuentes, J. M.; Munder, M.; Modolell, M.; Kropf, P.: Age-Related alteration of Arginase Activity Impacts on Severity of Leishmaniasis. PLoS Neglected Tropical Diseases 2, pp. 1 - 10 (2008)

Kropf, P.; Baud, D.; Marshall, S. E.; Munder, M.; Mosley, A.; Fuentes, J.; Bangham, C. R. M.; Taylor, G. P.; Herath, S.; Choi, B.-S. et al.; Soler, G.; Teoh, T.; Modolell, M.; Müller, I.: Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. European Journal of Immunology 37, pp. 935 - 945 (2007)

Munder, M.; Schneider, H.; Luckner, C.; Giese, T.; Langhans, C.-D.; Fuentes, J. M.; Kropf, P.; Mueller, I.; Kolb, A.; Modolell, M. et al.; Ho, A. D.: Suppression of T-cell functions by human granulocyte arginase. Blood 108, pp. 1627 - 1634 (2006)

Martin, L.; Comalada, M.; Marti, L.; Closs, E. I.; MacLeod, C. L.; del Rio, R. M.; Zorzano, A.; Modolell, M.; Celada, A.; Palacin, M. et al.; Bertran, J.: Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages. American Journal of Cell Physiology/Cell Physiology 290, pp. C1364 - C1372 (2006)

Yeramian, A.; Martin, L.; Arpa, L.; Bertran, J.; Soler, C.; McLeod, C.; Modolell, M.; Palacín, M.; Lloberas, J.; Celada, A.: Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation. European Journal of Immunology 36, pp. 1516 - 1526 (2006)

Yeramian, A.; Martin, L.; Serrat, N.; Arpa, L.; Soler, C.; Bertran, J.; McLeod, C.; Palacín, M.; Modolell, M.; Lloberas, J. et al.; Celada, A.: Arginine Transport via Cationic Amino Acid Transporter 2 Plays a Critical Regulatory Role in Classical or Alternative Activation of Macrophages. The Journal of Immunology 176, pp. 5918 - 5924 (2006)

Martin, P.; Wallich, R.; Pardo, J.; Müllbacher, A.; Munder, M.; Modolell, M.; Simon, M. M.: Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes? Blood 106, pp. 2871 - 2878 (2005)

Munder, M.; Mollinedo, F.; Calafat, J.; Canchado, J.; Gil-Lamaignere, C.; Fuentes, J. M.; Luckner, C.; Doschko, G.; Soler, G.; Eichamnn, K. et al.; Müller, F.-M.; Ho, A. D.; Goerner, M.; Modolell, M.: Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 105, pp. 2549 - 2556 (2005)

Kropf, P.; Fuentes, J. M.; Fähnrich, E.; Arpa, L.; Herath, S.; Weber, V.; Soler, G.; Celada, A.; Modolell, M.; Müller, I.: Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. The FASEB Journal 19, pp. 1000 - 1002 (2005)

Kropf, P.; Freudenberg, M. A.; Modolell, M.; Price, H. P.; Herath, S.; Antoniazi, S.; Galanos, C.; Smith, D. F.; Müller, I.: Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan Parasite Leishmania major. Infection and Immunity 72, pp. 1920 - 1928 (2004)

Kropf, P.; Freudenberg, N.; Kalis, C.; Modolell, M.; Herath, S.; Galanos, C.; Freudenberg, M.; Müller, I.: Infection of C57BL/10ScCr and C57/BL10ScNCR mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication. Journal of Leukocyte Biology 76, pp. 48 - 57 (2004)

Moreira, C.; Tsuhako, M. H.; de Franco, M. T.; Modolell, M.; Pereira, C. A.: Arginine metabolism during macrophage autocrine activation and infection with mouse hepatitis virus 3. Immunobiology 209, pp. 585 - 598 (2004)

Pereira, C. A.; Modolell, M.; Frey, J. R.; Lefkovits, I.: Gene expression in IFN-γ-activated murine macrophages. Brazilian Journal of Medical and Biologcial Research 37, pp. 1795 - 1809 (2004)

Soler, C.; Felipe, A.; García-Manteiga, J.; Serra, M.; Guillén-Gómez, E.; Casado, F. J.; MacLeod, C.; Modolell, M.; Pastor-Anglada, M.; Celada, A.: Interferon-γ regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Biochemical Journal 375, pp. 777 - 783 (2003)

Jost, M. M.; Ninci, E.; Meder, B.; Kempf, C.; van Royen, N.; Hua, J.; Berger, B.; Hoefer, I.; Modolell, M.; Buschmann, I.: Divergent effects of GM-CSF and TGFβ₁ on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix-metalloproteinase-12: a potential role during arteriogenesis. FASEB Journal 17 (13), pp. 2281 - 2293 (2003)

Kropf, P.; Herath, S.; Weber, V.; Modolell, M.; Müller, I.: Factors influencing Leishmania major infection in IL-4-deficient BALB/c mice. Parsite Immunology 25, pp. 439 - 447 (2003)

Hesse, M.; Modolell, M.; La Flamme, A. C.; Schito, M.; Fuentes, J. M.; Cheever, A. W.; Pearce, E. J.; Wynn, T. A.: Differential regulation of NO Synthase-2 and Arginase-1 by Type1/Type2 cytokines controls pathology in murine schistosomiasis. FASEB Journal 16 (5), p. A1225 - A1225 (2002)

Hesse, M.; Modolell, M.; La Flamme, A.; Schito, M.; Fuentes, J.; Cheever, A. W.; Pearce, E. J.; Wynn, T. A.: Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by type 1/Type 2 Cytokines in Vivo: Granulomatous Pathology is Shaped by the Pattern of L-Arginine Metabolism. Journal of Immunology 167 (11), pp. 6533 - 6544 (2001)