Publications of Markus M. Simon

Zorn, C. N.; Pardo, J.; Martin, P.; Kuhny, M.; Simon, M. M.; Huber, M.: Secretory lysosomes of mouse mast cells store and exocytose active caspase-3 in a strictly granzyme B dependent manner. European Journal of Immunology 43, pp. 3209 - 3218 (2013)

Joeckel, L. T.; Wallich, R.; Metkar, S. S.; Froelich, C. J.; Simon, M. M.; Borner, C.: Interleukin-1R Signaling Is Essential for Induction of Proapoptotic CD8 T cells, Viral Clearance, and Pathology during Lymphocytic Choriomeningitis Virus Infection in Mice. Journal of Virology 86, pp. 8713 - 8719 (2012)

Martin, P.; Pardo, J.; Schill, N.; Jöckel, L.; Berg, M.; Froehlich, C. J.; Wallich, R.; Simon, M. M.: Granzyme B-induced and Caspase 3-dependent Cleavage of Gelsolin by Mouse Cytotoxic T Cells Modifies Cytoskeleton Dynamics. The Journal of Biological Chemistry 285, pp. 18918 - 18927 (2010)

Grosskinsky, S.; Schott, M.; Brenner, C.; Cutler, S. J.; Simon, M. M.; Wallich, R.: Human Complement Regulators C4b-Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis. PLoS Neglected Tropical Diseases 4, p. e698 - e698 (2010)

Weber, F. C.; Esser, P. R.; Müller, T.; Ganesan, J.; Pellegatti, P.; Simon, M. M.; Zeiser, R.; Idzko, M.; Jakob, T.; Martin, S. F.: Lack of the purinergic receptor P2X₇ results in resistance to contact hypersensitivity. The Journal of Experimental Medicine 27, pp. 1545 - 1553 (2010)

Froehlich, C. J.; Pardo, J.; Simon, M. M.: Granule-associated serine proteases: granzymes might not just be killer proteases. Cell 30, pp. 117 - 123 (2009)

Grosskinsky, S.; Schott, M.; Brenner, C.; Cutler, S. J.; Kraiczy, P.; Zipfel, P. F.; Simon, M. M.; Wallich, R.: Borrelia recurrentis Employs a Novel Multifunctional Surface Protein with Anti-Complement, Anti-Opsonic and Invasive Potential to Escape Innate Immunity. PLoS ONE 4, p. e4858 - e4858 (2009)

Herz, J.; Pardo, J.; Kashkar, H.; Schramm, M.; Kuzmenkina, E.; Bos, E.; Wiegmann, K.; Wallich, R.; Peters, P. J.; Herzig, S. et al.; Schmelzer, E.; Krönke, M.; Simon, M. M.; Utermöhlen, O.: Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes. Nature Immunology 10, pp. 761 - 768 (2009)

Kraiczy, P.; Hanssen-Hübner, C.; Kitiratschky, V.; Brenner, C.; Besier, S.; Brade, V.; Simon, M. M.; Skerka, C.; Roversi, P.; Lea, S. M. et al.; Stevenson, B.; Wallich, R.; Zipfel, P. F.: Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H. International Journal of Medical Microbiology 299, pp. 255 - 268 (2009)

Kudryashev, M.; Cyrklaff, M.; Baumeister, W.; Simon, M. M.; Wallich, R.; Frischknecht, F.: Comparative cryo-electron tomography of pathogenic Lyme disease spirochetes. Molecular Microbiology 71, pp. 1415 - 1434 (2009)

Metkar, S. S.; Menaa, C.; Pardo, J.; Wang, B.; Wallich, R.; Freudenberg, M.; Kim, S.; Raja, S.; Shi, L.; Simon, M. M. et al.; Froelich, C. J.: Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response. Immunity 29, pp. 720 - 733 (2008)

Gumenscheimer, M.; Balkow, S.; Simon, M. M.; Jirillo, E.; Galanos, C.; Freudenberg, M. A.: Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections. Medical Microbiology and Immunology 196, pp. 79 - 88 (2007)

Nassal, M.; Skamel, C.; Vogel, M.; Kratz, P. A.; Stehle, T.; Wallich, R.; Simon, M. M.: Development of hepatitis B virus capsids into a whole-chain protein antigen display platform: New particulate Lyme disease vaccines. International Journal of Medical Microbiology 298, pp. 135 - 142 (2007)

Rossmann, E.; Kraiczy, P.; Herzberger, P.; Skerka, C.; Kirschfink, M.; Simon, M. M.; Zipfel, P. F.; Wallich, R.: Dual Binding Specificity of a Borrelia hermsii-Associated Complement Regulator-Acquiring Surface Protein for Factor H and Plasminogen Discloses a Putative Virulence Factor of Relapsing Fever Spirochetes. Journal of Immunology 178, pp. 7292 - 7301 (2007)

Sugui, J. A.; Pardo, J.; Chang, Y. C.; Müllbacher, A.; Zarember, K. A.; Galvez, E. M.; Brinster, L.; Zerfas, P.; Gallin, J. I.; Simon, M. M. et al.; Kwon-Chung, K. J.: Role of laeA in the Regulation of alb1, gliP, Conidial Morphology, and Virulence in Aspergillus fumigatus. Eukaryotic Cell 6, pp. 1552 - 1561 (2007)

Sugui, J. A.; Pardo, J.; Chang, Y. C.; Zarember, K. A.; Nardone, G.; Galvez, E. M.; Müllbacher, A.; Gallin, J. I.; Simon, M. M.; Kwon-Chung, K. J.: Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone. Eukaryotic Cell 6, pp. 1562 - 1569 (2007)

Zelinskyy, G.; Balkow, S.; Schimmer, S.; Werner, T.; Simon, M. M.; Dittmer, U.: The Level of Friend Retrovirus Replication Determine sthe Cytolytic Pathway of CD8⁺ T-Cell-Mediated Pathogen Control. Journal of Virology 81, pp. 11881 - 11890 (2007)

Rossmann, E.; Kitiratschky, V.; Hofmann, H.; Kraiczy, P.; Simon, M. M.; Wallich, R.: Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 1 of the Lyme Disease Spirochetes Is Expressed in Humans and Induces Antibody Responses Restricted to Nondenatured Structural Determinants. Infection and Immunity 74, pp. 7024 - 7028 (2006)

Pardo, J.; Urban, C.; Galvez, E. M.; Ekert, P. G.; Müller, U.; Kwon-Chung, J.; Lobigs, M.; Müllbacher, A.; Wallich, R.; Borner, C. et al.; Simon, M. M.: The motchondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. The Journal of Cell Biology 174, pp. 509 - 519 (2006)

Skamel, C.; Ploss, M.; Böttcher, B.; Stehle, T.; Wallich, R.; Simon, M. M.; Nassal, M.: Hepatitis B Virus Capsid-like Particles Can Display the Complete, Dimeric Outer Surface Protein C and Stimulate Production of Protective Antibody Responses against Borrelia burgdorferi Infection. The Journal of Biological Chemistry 281, pp. 17474 - 17481 (2006)

Alsharifi, M.; Lobigs, M.; Simon, M. M.; Kersten, A.; Müller, K.; Koskinen, A.; Lee, E.; Müllbacher, A.: NK cell-mediated immunopathology during an acute viral infection of the CNS. European Journal of Immunology 36, pp. 887 - 896 (2006)

Cordes, F. S.; Kraiczy, P.; Roversi, P.; Simon, M. M.; Brade, V.; Jahraus, O.; Wallis, R.; Goodstadt, L.; Ponting, C. P.; Skerka, C. et al.; Zipfel, P. F.; Wallich, R.; Lea, S. M.: Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi. International Journal of Medical Microbiology 296 S1, pp. 177 - 184 (2006)

Glenz, K.; Bouchon, B.; Stehle, T.; Wallich, R.; Simon, M. M.; Warzecha, H.: Production of a recombinant bacterial lipoprotein in higher plant chloroplasts. Nature Biotechnology 24, pp. 76 - 77 (2006)

Kraiczy, P.; Rossmann, E.; Brade, V.; Simon, M. M.; Skerka, C.; Zipfel, P. F.; Wallich, R.: Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi. Wiener Klinische Wochenschrift 118, pp. 669 - 676 (2006)

Martin, P.; Wallich, R.; Pardo, J.; Müllbacher, A.; Munder, M.; Modolell, M.; Simon, M. M.: Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes? Blood 106, pp. 2871 - 2878 (2005)

Wallich, R.; Pattathu, J.; Kitiratschky, V.; Brenner, C.; Zipfel, P. F.; Brade, V.; Simon, M. M.; Kraiczy, P.: Identification and Functional Characterization of Complement Regulator-Acquiring Surface Protein 1 of the Lyme Disease Spirochetes Borrelia afzelii and Borrelia garinii. Infection and Immunity 73, pp. 2351 - 2359 (2005)

Cordes, F. S.; Roversi, P.; Kraiczy, P.; Simon, M. M.; Brade, V.; Jahraus, O.; Wallis, R.; Skerka, C.; Zipfel, P. F.; Wallich, R. et al.; Lea, S. M.: A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi. Nature Structural & Molecular Biology 12, pp. 276 - 277 (2005)

Ghielmatti, M.; Zwicker, M.; Ghielmetti, T.; Simon, M. M.; Villiger, P. M.; Padovan, E.: Synthetic bacterial lipopeptide analogs facilitate naive CD4⁺ T cell differentiation and enhance antigen-specific HLA-II-restricted responses. European Journal of Immunology 35, pp. 2434 - 2442 (2005)

Nassal, M.; Skamel, C.; Kratz, P. A.; Wallich, R.; Stehle, T.; Simon, M. M.: A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula. European Journal of Immunology 35, pp. 655 - 665 (2005)

Pardo, J.; Bosque, A.; Brehm, R.; Wallich, R.; Naval, J.; Müllbacher, A.; Anel, A.; Simon, M.: Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. The Journal of Cell Biology 167, pp. 457 - 468 (2004)