Publikationen von Asifa Akhtar

Zeitschriftenartikel (69)

2019
Zeitschriftenartikel
Lam, K.-C.; Chung, H.-R.; Semplicio, G.; Iyer, S. S.; Gaub, A.; Bhardwaj, V.; Holz, H.; Georgiev, P.; Akhtar, A.: The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Genes and Development 33, S. 453 - 465 (2019)
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Zeitschriftenartikel
Sheikh, B.; Akhtar, A.: Many lives of KATs - detector, integrator and modulator of cellular environment. Nature Reviews Genetics 20, S. 7 - 23 (2019)
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2018
Zeitschriftenartikel
Basilicata, M. F.; Bruel, A.-L.; Semplicio, G.; Keller Valsecchi, C. I.; Aktaş, T.; Duffourd, Y.; Rumpf, T.; Morton, J.; Bache, I.; Szymanski, W. G. et al.; Gilissen, C.; Vanakker, O.; Õunap, K.; Mittler, G.; van der Burgt, I.; Chehadeh, S. E.; Cho, M. T.; Pfundt, R.; Tan, T. Y.; Kirchhoff, M.; Menten, B.; Vergult, S.; Lindstrom, K.; Reis, A.; Johnson, D. S.; Fryer, A.; McKay, V.; Study, D.; Fisher, R. B.; Thauvin-Robinet, C.; Francis, D.; Roscioli, T.; Pajusalu, S.; Radtke, K.; Ganesh, J.; Brunner, H. G.; Wilson, M.; Faivre, L.; Kalscheuer, V. M.; Thevenon , J.; Akhtar, A.: De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Nature Genetics, S. 1442 - 1451 (2018)
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Akhtar, A.: Finding your way through the science maze. Nature Genetics 20, S. 1000 (2018)
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Zeitschriftenartikel
Samata, M.; Akhtar, A.: Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs. Annual Review of Biochemistry 87, S. 323 - 350 (2018)
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Ramirez, F.; Bhardwaj, V.; Arrigoni, L.; Lam, K. C.; Grüning, B. A.; Villaveces, J.; Habermann, B.; Akhtar, A.; Manke, T.: High-resolution TADs reveal DNA sequences underlying genome organization in flies. Nature Communications 9, S. 189 (2018)
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Zeitschriftenartikel
Maticzka, D.; Ilik, I. A.; Aktas, T.; Backofen, R.; Akhtar, A.: uvCLAP is a fast and non-radioactive method to identify in vivo targets of RNA-binding proteins. Nature Communications 9, S. 1142 (2018)
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Zeitschriftenartikel
Valsecchi Keller, C. I.; Basilicata , M. F.; Semplicio, G.; Georgiev, P.; Gutierrez, N. M.; Akhtar, A.: Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Nature Communications 9, S. 3926 (2018)
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2017
Zeitschriftenartikel
Ilik, I. A.; Maticzka, D.; Georgiev, P.; Gutierrez, N. M.; Backofen, R.; Akhtar, A.: A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila. Genes and Development 31, S. 1973 - 1987 (2017)
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Zeitschriftenartikel
Aktas, T.; Ilik, I. A.; Maticzka, D.; Bhardwaj, V.; Rodrigues , C. P.; Mittler, G.; Manke, T.; Backofen, R.; Akhtar, A.: DHX9 Suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature 544, S. 115 - 119 (2017)
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2016
Zeitschriftenartikel
Chatterjee, A.; Seyfferth, J.; Lucci, J.; Glisbach, R.; Preissl, S.; Böttinger, L.; Martensson, C. U.; Panhale, A.; Stehle, T.; Kretz, O. et al.; Sahyoun, A. H.; Avilov, S.; Eimer, S.; Hein, L.; Pfanner, N.; Becker, T.; Akhtar, A.: MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria. Cell 167, S. 722 - 738 (2016)
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Zeitschriftenartikel
Sheikh, B.N.; Bechtel-Walz, W.; Lucci, J.; Karpuik, O.; Hild, I.; Hartleben, B.; Vornweg, J.; Helmstädter, M.; Sahyoun, A.H.; Bhardwaj, V. et al.; Stehle, T.; Diehl, S.; Kretz, O.; Voss, A.K.; Thomas, T.; Manke, T.; Huber, T.B.; Akhtar, A.: MOF maintains transcriptional programs regulating cellular stress response. Oncogene 35, S. 2698 - 2710 (2016)
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Zeitschriftenartikel
Quinn, J. J.; Zhang, Q. C.; Georgiev, P.; Ilik, I. A.; Akhtar, A.; Chang, H. Y.: Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes and Development 30, S. 191 - 207 (2016)
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Zeitschriftenartikel
Chlamydas, S.; Holz, H.; Samata, M.; Chelmicki, T.; Georgiev, P.; Pelechano, V.; Dündar, F.; Dasmeh, P.; Mittler, G.; Tavares Cadete, F. et al.; Ramirez, F.; Conrad, T.; Wei, W.; Raja, S.; Manke, T.; Luscombe, N. M.; Steinmetz, L. M.; Akhtar, A.: Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nature Structural and Molecular Biology 23, S. 580 - 589 (2016)
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2015
Zeitschriftenartikel
Ramirez, F.; Lingg, T.; Toscano, S.; Lam, K.-C.; Georgiev, P.; Chung, H.-R.; Lajoie, B. R.; de Wit, E.; Zhan, Y.; de laat, W. et al.; Dekker, J.; Manke, T.; Akhtar, A.: High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Molecular Cell 60, S. 146 - 162 (2015)
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Zeitschriftenartikel
Meunier, S.; Shvedunova, M.; Van Nguyen, N.; Avila, l.; Vernos, I.; Akhtar, A.: An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature Communications 6, 7889 (2015) (2015)
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Zeitschriftenartikel
Keller, C. I.; Akhtar, A.: The MSL complex: juggling RNA-protein interaction for dosage compensation and beyond. Current Opinion in Genetics & Development 31, S. 1 - 11 (2015)
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2014
Zeitschriftenartikel
Furdas, S. D.; Hoffmann, I.; Robaa, D.; Herquel, B.; Malinka, W.; Świątek, P.; Akhtar, A.; Sippl, W.; Jung, M.: Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs). Medicinal Chemistry Communications 5, S. 1856 - 1862 (2014)
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publisher-version
Zeitschriftenartikel
Bassett, A. R.; Akhtar, A.; Barlow, D. P.; Bird, A. P.; Brockdorff, N.; Duboule, D.; Ephrussi, A.; Ferguson-Smith, A. C.; Gingeras, T. R.; Haerty, W. et al.; Higgs, D. R.; Miska, E. A.; Ponting, C. P.: Considerations when investigating IncRNA function in vivo. eLife 3, e03058 (2014)
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Chelmicki, T.; Dündar, F.; Turley, M. J.; Khanam, T.; Aktas, T.; Ramírez, F.; Gendrel, A.-V.; Wright, P. R.; Videm, P.; Backofen, R. et al.; Heard, E.; Manke, T.; Akhtar, A.: MOF-associated complexes ensure stem cell identity and Xist repression. eLife 3, S. e02024 (2014)
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publisher-version
Zeitschriftenartikel
Dias, J.; Van Nguyen, N.; Georgiev, P.; Gaub, A.; Brettschneider, J.; Cusack, S.; Kadlec, J.; Akhtar, A.: Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. Genes and Development 28, S. 929 - 942 (2014)
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Zeitschriftenartikel
Quinn, J. J.; Ilik, I. A.; Qu, K.; Georgiev, P.; Chu, C.; Akhtar, A.; Chang, H. Y.: Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Nature biotechnology 32, S. 933 - 940 (2014)
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2013
Zeitschriftenartikel
Ilik, I. A.; Quinn, J.; Georgiev, P.; Tavares-Cadete, F.; Maticzka, D.; Toscano, S.; Wan, Y.; Spitale, R. C.; Luscombe, N.; Backofen, R. et al.; Chang, H. Y.; Akhtar, A.: Tandem Stem-Loops in roX RNAs Act Together to Mediate X Chromsome Dosage Compensation in Drosophila. Molecular Cell 51, S. 156 - 173 (2013)
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2012
Zeitschriftenartikel
Hallacli, E.; Lipp, M.; Georgiev, P.; Spielman, C.; Cusack, S.; Akhtar, A.; Kadlec, J.: Msl1-Mediated Dimerization of the Dosage Compensation Complex is Essential for Male X-Chromosome Regulation in Drosophila. Molecular Cell 48, S. 587 - 600 (2012)
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Zeitschriftenartikel
Conrad, T.; Cavalli, F. M. G.; Vaquerizas, J. M.; Luscombe, N. M.; Akhtar, A.: Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters. Science 337, S. 742 - 746 (2012)
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Zeitschriftenartikel
Lam, K. C.; Mühlpfordt, F.; Vaquerizas, J. M.; Raja, S. J.; Holz, H.; Luscombe, N. M.; Manke, T.; Akhtar, A.: The NSL Complex Regulates Housekeeping Genes in Drosophila. PLoS Genetics 8, S. e1002736 - e1002736 (2012)
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Zeitschriftenartikel
Conrad, T.; Cavalli, F. M. G.; Holz, H.; Hallacli, E.; Kind, J.; Ilik, I.; Vaquerizas, J. M.; Luscombe, N. M.; Akhtar, A.: The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex. Developmental Cell 22, S. 610 - 624 (2012)
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Zeitschriftenartikel
Conrad, T.; Akhtar, A.: Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews Genetics 13, S. 123 - 134 (2012)
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2011
Zeitschriftenartikel
Akhtar, A.; Fuchs, E.; Mitchison, T.; Shaw, R. J.; St Johnston, D.; Strasser, A.; Taylor, S.; Walczak, C.; Zerial, M.: A decade of molecular cell biology: achievements and challenges. Nature Reviews Molecular Cell Biology 12, S. 669 - 674 (2011)
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Zeitschriftenartikel
Georgiev, P.; Chlamydas, S.; Akhtar, A.: Drosophila dosage compensation: males are from Mars, females are from Venus. Fly 5, S. 147 - 154 (2011)
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