Publikationen von Edward Jonathen Pearce

Zeitschriftenartikel (85)

2024
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Bohnacker, S.; Henkel, F. D. R.; Hartung, F.; Geerlof, A.; Riemer, S.; Prodjinotho, U. F.; Salah, E. B.; Mourão, A. S. D.; Bohn, S.; Teder, T. et al.: A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis. Science Immunology 9, eadl1467 (2024)
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Villa, M.; Sanin, D. E.; Apostolova, P.; Corrado, M.; Kabat, A. M.; Cristinzio, C.; Regina, A.; Carrizo, G. E.; Rana, N.; Stanczak, M. A. et al.: Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment. Nature Communications 15, 451 (2024)
2023
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Castoldi, A.; Sanin, D. E.; van Bakker, N. T.; Aguiar, C. F.; de Monteiro, L. B.; Rana, N.; Grzes, K. M.; Kabat, A. M.; Curtis, J.; Cameron, A. M. et al.: Metabolic and functional remodeling of colonic macrophages in response to high-fat diet-induced obesity. iScience 26, 107719 (2023)
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Forde, A. J.; Kolter, J.; Zwicky, P.; Baasch, S.; Lohrmann, F.; Eckert, M.; Gres, V.; Lagies, S.; Gorka, O.; Rambold, A. et al.: Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection. Science Immunology 8, eadg3517 (2023)
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Edwards-Hicks, J.; Apostolova, P.; Büscher, J. M.; Maib, H.; Stanczak, M. A.; Corrado, M.; Geltink, R. I. K.; Maccari, M. E.; Villa, M.; Carrizo, G. E. et al.: Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function. Nature Immunology 24, S. 516 - 530 (2023)
2022
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Kabat, A. M.; Hackl, A.; Sanin, D. E.; Zeis, P.; Grzes, K. M.; Baixauli, F.; Kyle, R.; Caputa, G.; Edwards-Hicks, J.; Villa, M. et al.: Resident TH2 cells orchestrate adipose tissue remodeling at a site adjacent to infection. Science Immunology 7, eadd3263 (2022)
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Baixauli, F.; Piletic, K.; Puleston, D. J.; Villa, M.; Field, C. S.; Flachsmann, L. J.; Quintana, A.; Rana, N.; Edwards-Hicks, J.; Matsushita, M. et al.: An LKB1-mitochondria axis controls TH17 effector function. Nature 610, S. 555 - 561 (2022)
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Zahalka, S.; Starkl, P.; Watzenboeck, M. L.; Farhat, A.; Radhouani, M.; Deckert, F.; Hladik, A.; Lakovits, K.; Oberndorfer, F.; Lassnig, C. et al.: Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling. Mucosal immunology: official journal of the Society for Mucosal Immunology 15, S. 896 - 907 (2022)
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Caputa, G.; Matsushita, M.; Sanin, D. E.; Kabat, A. M.; Edwards-Hicks, J.; Grzes, K. M.; Pohlmeyer, R.; Stanczak, M. A.; Castoldi, A.; Cupovic, J. et al.: Intracellular infection and immune system cues rewire adipocytes to acquire immune function. Cell Metabolism 34, S. 747 - 760 (2022)
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Sanin, D. E.; Ge, Y.; Marinkovic, E.; Kabat, A. M.; Castoldi, A.; Caputa, G.; Grzes, K. M.; Curtis, J. D.; Thompson, E. A.; Willenborg, S. et al.: A common framework of monocyte-derived macrophage activation. Science Immunology 7, eabl7482 (2022)
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Dichtl, S.; Sanin, D. E.; Koss, C. K.; Willenborg, S.; Petzold, A.; Tanzer, M. C.; Dahl, A.; Kabat, A. M.; Lindenthal, L.; Zeitler, L. et al.: Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF. Life science alliance 5, e202101315 (2022)
2021
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Lechner, A.; Henkel, F. D. R.; Hartung, F.; Bohnacker, S.; Alessandrini, F.; Gubernatorova, E. O.; Drutskaya, M. S.; Angioni, C.; Schreiber, Y.; Haimerl, P. et al.: Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma. The journal of allergy and clinical immunology: official publication of the American Academy of Allergy, Asthma and Immunology 149, S. 2078 - 2090 (2021)
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Willenborg, S.; Sanin, D. E.; Jais, A.; Ding, X.; Ulas, T.; Nüchel, J.; Popović, M.; MacVicar, T.; Langer, T.; Schultze, J. L. et al.: Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism 33, S. 2398 - 2414 (2021)
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Grzes, K. M.; Sanin, D. E.; Kabat, A. M.; Stanczak, M. A.; Edwards-Hicks, J.; Matsushita, M.; Hackl, A.; Hässler, F.; Knoke, K.; Zahalka, S. et al.: Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters. Immunity 54, S. 2514 - 2530 (2021)
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Erny, D.; Dokalis, N.; Mezö, C.; Castoldi, A.; Mossad, O.; Staszewski, O.; Frosch, M.; Villa, M.; Fuchs, V.; Mayer, A. et al.: Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease. Cell Metabolism 33, S. 2260 - 2276 (2021)
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Knoke, K.; Rongisch, R. R.; Grzes, K. M.; Schwarz, R.; Lorenz, B.; Yogev, N.; Pearce, E. L.; Pearce, E. J.; Kofler, D. M.; Fabri, M.: Tofacitinib Suppresses IL-10/IL-10R Signaling and Modulates Host Defense Responses in Human Macrophages. The Journal of Investigative Dermatology: Official Journal of the Society for Investigative Dermatology and the European Society for Dermatological Research 142, S. 559 - 570 (2021)
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Puleston, D. J.; Baixauli, F.; Sanin, D. E.; Edwards-Hicks, J.; Villa, M.; Kabat, A. M.; Kamiński, M. M.; Stanckzak, M.; Weiss, H. J.; Grzes, K. M. et al.: Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell 184, S. 4186 - 4202 (2021)
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O'Sullivan, D.; Stanczak, M. A.; Villa, M.; Uhl, F. M.; Corrado, M.; Geltink, R. I. K.; Sanin, D. E.; Apostolova, P.; Rana, N.; Edwards-Hicks, J. et al.: Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. Proceedings of the National Academy of Sciences of the United States of America 118, e2023752118 (2021)
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Dudek, M.; Pfister, D.; Donakonda, S.; Filpe, P.; Schneider, A.; Laschinger, M.; Hartmann, D.; Hüser, N.; Meiser, P.; Bayerl, F. et al.: Auto-aggressive CXCR6 CD8 T cells cause liver immune pathology in NASH. Nature 592, S. 444 - 449 (2021)
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Stanczak, M. A.; Sanin, P. D. E.; Apostolova, P.; Nerz, G.; Lampaki, D.; Hofmann, M.; Steinmann, D.; Krohn-Grimberghe, M.; Thimme, R.; Mittler, G. et al.: IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nature Communications 12, 2133 (2021)
2020
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Kapoor, T.; Corrado, M.; Pearce, E. L.; Pearce, E. J.; Grosschedl, R.: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Scientific Reports 10, 21626 (2020)
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Corrado, M.; Edwards-Hicks, J.; Villa, M.; Flachsmann, L. J.; Sanin, P. D. E.; Jacobs, M.; Baixauli Celda, F.; Stanczak, M.; Anderson, E.; Azuma, M. et al.: Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell Metabolism 32, S. 981 - 995 (2020)
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Remmerie, A.; Martens, L.; ́Thone, T.; Castoldi, A.; Seurinck, R.; Pavie, B.; Roels, J.; Vanneste, B.; Prijck, S. D.; Vanhockerhout, M. et al.: Osteopontin Expression Identifies a Subsetof Recruited Macrophages Distinctfrom Kupffer Cells in the Fatty Liver. Immunity 53, S. 641 - 657 (2020)
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Klein-Geltink, R.; Edwards-Hicks, J.; Apostolova, P.; O'Sullivan, D.; Sanin, P. D. E.; Annette, E. P.; Puleston, D.; Ligthart, N. A. M.; Büscher, J. M.; Grzes, K. et al.: Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. Nature Metabolism 2, S. 703 - 716 (2020)
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van Teijlingen Bakker, N.; Pearce, E. J.: Cell-intrinsic metabolic regulation of mononuclear activation: Findings from the tip of the iceberg. Immunological Reviews 295, S. 54 - 67 (2020)
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Field, C.; Baixauli Celda, F.; Puleston, D.; Kyle, R.; Alana, C.; Sanin, P. D. E.; Hippen, K. L.; Loschi, M.; Thangavelu, G.; Corrado, M. et al.: Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function. Cell Metabolism 31, S. 422 - 437 (2020)
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Castoldi, A.; Monteiro, L. B.; van Bakker, N. T.; Sanin, D. E.; Rana, N.; Corrado, M.; Cameron, A. M.; Hässler, F.; Matsushita, M.; Caputa, G. et al.: Triacylglycerol synthesis enhances macrophage inflammatory function. Nature Communications 11, S. 1 - 11 (2020)
2019
Zeitschriftenartikel
Puleston, D. J.; Buck, M. D.; Geltink, R. I. K.; Kyle, R. L.; Caputa, G.; O’Sullivan, D.; Cameron, A. M.; Castoldi, A.; Musa, Y.; Kabat, A. M. et al.: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism 30, S. 352 - 363 (2019)
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Caputa, G.; Castoldi, A.; Pearce, E. J.: Metabolic adaptations of tissue-resident immune cells. Nature Immunology 20, S. 793 - 801 (2019)
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Qiu, J.; Villa, M.; Sanin, P. D. E.; Buck, M. D.; O’Sullivan, D.; Ching, R. W.; Matsushita, M.; Grzes, K.; Winkler, F.; Chang, C.-H. et al.: Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Reports 27, S. 2063 - 2074 (2019)
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